The article deals with the organization of the work of the trade unions of the Kuban and Stavropol Territories in wartime conditions. The nature of the restructuring of the activities of the trade unions with the beginning of the Great Patriotic War is analyzed, attention is drawn to the strengthening of the centralization of the trade union management system, the inclusion of the latter in the common cause of the struggle against the Nazi invaders. The problems of organizing trade union work associated with the weakening of the democratic foundations of the trade union movement and the violation of the principles of collegiality in discussing current issues are noted. An assessment of the consequences of the occupation of the Kuban and Stavropol Territory for the trade unions of the region is given. The process of restoring the activity of trade unions in the territory of the Krasnodar and Stavropol Territories is highlighted. The main attention is paid to strengthening the staff of trade union organizations. The main forms of training trade union workers are considered, positive and negative examples of work organization in individual trade union organizations of the Kuban and Stavropol Territory are given. The role of a trade union asset combining its labor and social activities is emphasized. The article describes the measures taken by the trade union committees to attract new members to the trade unions, as well as to solve the problem of paying membership dues. The study gives assessment of the results achieved by the end of the war in the organizational strengthening of the Kuban and Stavropol trade unions, the expansion of their participation in the industrial and social spheres, and the increase in their role in public and political life